The effect of low Glutathione levels in children suffering from attention deficit hyperactivity disorder (ADHD).
Redox Rep. 2006;11(4):163-72. Department of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
Attention deficit hyperactivity disorder (ADHD) belongs to the neurodevelopmental disorders characterized by impulsivity, distractibility and hyperactivity. In the pathogenesis of ADHD genetic and non-genetic factors play an important role. It is assumed that one of non-genetic factors could be oxidative stress.
This randomized, double-blind, placebo-controlled study investigated the influence of intercellular reduced Glutathione and oxidized Glutathione in children suffering from ADHD and total antioxidant status (TAS). This is the first investigation of the redox Glutathione state in relation to ADHD.
RESULTS: One month of Glutathione administration caused a significant decrease in oxidized Glutathione and a highly significant increase in Glutathione levels as well as improvement of Glutathione/oxidized Glutathione ratio in comparison to a group of patients taking a placebo. TAS in children with ADHD was decreased in comparison with reference values. Glutathione administration normalized the TAS of ADHD children in this study.
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