From an article by Ward Dean MD in Vitamin Research News.
Mitochondrial Glutathione is critical to the healthy cell, and is probably the most important antioxidant defense system within the mitochondria cell. Age-related alterations in these enzymes can have a profound adverse effect on health and longevity.
Age-Related Changes in Glutathione
Drs. J.P. Richie and Calvin Lang of the Department of Biochemistry, University of Louisville, were the first to propose that a Glutathione deficiency might be a biochemical cause of the aging process. They demonstrated that Glutathione blood levels predictably declined with age in healthy men and women ranging in age from 20 to 94.
Scientists at the University of Pavia found that Glutathione levels continue to decline with age. Subjects with the highest Glutathione levels survived the longest.
In another study of enzyme activity in the very old, Dr. Helle Anderson and colleagues at Odense University in Denmark compared the levels of Glutathione in 41 centenarians between 100-105 years old to that in 52 community controls between the ages of 60-79. They found that the mean Glutathione activity was significantly higher in centenarians than in the group of younger elderly subjects, and that centenarians with the best functional capacity tended to have the highest Glutathione levels.
Dr. Lang’s group evaluated Glutathione levels in 87 women in excellent physical and mental health, ranging in age from 60 to 103. The scientists found that all subjects had very high blood Glutathione levels. They followed these women for five years and concluded that “high blood Glutathione concentrations … are characteristic of long-lived women.”
Glutathione in Health and Disease
Just as high Glutathione levels are related to increased survival and longer life in all organisms tested so far, lower levels are related to poorer health and a number of chronic degenerative diseases, including heart disease, arthritis, hypertension, diabetes, cancer, genitourinary, gastrointestinal, and musculoskeletal diseases, age-related macular degeneration (ARMD), preeclampsia, cataracts, chronic renal failure, leukemia, respiratory diseases such as COPD and adult respiratory distress syndrome (ARDS), hearing loss, and AIDS.
Dr. Lang concluded that decreased Glutathione levels are risk factors for chronic diseases and may be used to monitor the severity and progress of the diseases.
Conversely, Dr. Mara Julius of the Department of Epidemiology, University of Michigan, in a study of 33 subjects over the age of 60, found that higher Glutathione levels were associated with fewer illnesses and higher levels of self rated health, lower cholesterol, lower body mass index and lower blood pressures. The author noted that this was the first study that showed an association of higher Glutathione levels with higher levels of physical health in a community-based sample.
Glutathione and Detoxification
One of Glutathione’s primary roles in the body is to detoxify a number of drugs and toxins. Acetaminophen (APAP, i.e.,Tylenol) has been studied intensively in regard to its Glutathione-depleting properties, and with regard to Glutathione’s ability to prevent APAP-induced liver and kidney damage. Since GSH Glutathione levels decrease with aging in all tissues, including the liver and kidney, older organisms are thus at even greater risk to APAP-induced liver and renal damage than younger organisms.
Increasing Tissue Glutathione Levels
It is clear that those with the highest Glutathione levels are likely to live the longest in the best of health.
Read this article in its entirety refer to “Vitamin Research News Vol. 20, Number 8 by Ward Dean, MD”.
The product that has been documented to produce high levels of Glutathione concentrations in the body is MaxGXL. http://MaxHealthProducts.Net/order.htm
Free 20-page eBook available "Glutathione Master Antioxidant" http://MaxHealthProducts.Net/ebook.htm
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